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For Cervical Dysplasia or Abnormal Pap Smear

Cervical Dysplasia is the abnormal growth of the epithelial tissue on the surface of the cervix. 

  • It refers to a spectrum or continuum of changes specified as: CIN I — mild dysplasia; CIN II — moderate to marked dysplasia; and CIN III — severe dysplasia to carcinoma-in-situ (cancer localized to the intraepithelial tissue/superficial layer of the cervix).
    Info Source: (US National Library of Medicine)

CERVAPLEXX I3C is:

  • Natural/non-toxic

  • Counteracts effect HPV has on estrogen ratio

  • Proven in double-blind study to reduce degree of HPV-caused cervical dysplasia

  • Our dosage is the same used in the study

  • Converts estradiol to weaker metabolites that can be flushed from body

A recent study (MS Word document) done between the Departments of Obstetrics and Gynecology at both the LSU Medical Center-Shreveport and Harvard Medical School and the Strang Cancer Research Laboratory provided convincing evidence that indole-3-carbinol can reverse HPV induced CIN.1

Fifty percent of patients enrolled in a recent study experienced regression from either CIN II or CIN III to Normal in just 12 weeks!  (See chart).  Further, all patients in the 400mg dosage group regressed to either CIN I or Normal.

 

Patient#
I3C (mg/day)		 Diagnosis2
week 1		 Diagnosis2
week 12		 Low-risk3
HPV		 High risk4
HPV		 HPV PCR
1.  placebo CIN II CIN I – pos pos
2.  placebo CIN II CIN I neg neg neg
3.  placebo CIN II CIN I neg pos –
4.  placebo CIN III CIN I neg pos –
5.  placebo CIN III CIN I neg neg pos
6.  placebo CIN II CIN I neg neg –
7.placebo CIN II CIN I neg neg –
8.  placebo CIN III CIN III neg pos –
9.  placebo CIN III CIN I neg pos –
10.  placebo CIN III CIN III neg pos –
11.  400 CIN II CIN I neg neg pos
12.  400 CIN II CIN I neg pos pos
13.  400 CIN III CIN I neg pos –
14.  400 CIN II CIN I neg neg neg
15.  400 CIN II normal neg neg pos
16.  400 CIN III CIN I neg pos pos
17.  400 CIN II normal neg neg pos
18.  400 CIN III normal neg neg pos
19.  400 CIN II normal neg pos –
20.  200 CIN III CIN I – pos pos
21.  200 CIN II normal neg pos –
22.  200 CIN III CIN III neg neg neg
23.  200 CIN II normal neg pos –
24.  200 CIN III normal pos pos –
25.  200 CIN II CIN II pos pos –
26.  200 CIN II normal neg neg pos
27.  200 CIN II CIN II neg pos –

 

2Diagnosis by biopsy      3HPV Types 6,11,42,43,44      4HPV Types 16,18,31,33,35,45,51,52,56
List of abbreviations:  mg/day – milligrams per day    HPV– human papillomavirus    CIN – cervical intraepithelial neoplastia    PCR – polymerase chain reaction    neg – negative    pos – positive                      

The basis for this study was indole-3-carbinol’s efficacy against laryngeal papillomas that are typically caused by HPV strains 6 and 11.  These are the same strains that cause genital warts; therefore, it may be hypothesized that the indole-3-carbinol would also be effective against genital warts.

The proposed mechanism of indole-3-carbinol resides in its ability to convert estradiol to 2-OH-estrone rather than the potentially carcinogenic 16a-OH-estrone.  It is believed that HPV alters the estrogen ratio toward 16a-OH-estrone.  The indole-3-carbinol reverses this trend.

Cervaplexx I3C™ (30 capsules is one month’s supply) is now available without a prescription in 400mg capsules.  It contains pure indole-3-carbinol, a natural substance found in cruciferous vegetables (400mg  = about 1/3 head of cabbage).  There is no noted toxicity.

References

1Bell, M.C., Crowley-Nowick, P., Bradlow, H.L., et al., 1999, “Indole-3-carbinol in the treatment of CIN”, Society of Gynecologic Oncologists, San Francisco, CA.

WE RECOMMEND A 12 WEEK (3 BOTTLE) DOSAGE PERIOD TO EVALUATE HOW EFFECTIVE CERVAPLEXX I3C WILL BE FOR YOU, AS THIS WAS THE TIME FRAME OF THE STUDY.  ACCORDINGLY, WE ARE NOW OFFERING  A 3 BOTTLE TRIAL/REFILL PACK (BUY 2 BOTTLES & GET 1 BOTTLE FREE) FOR BOTH NEW AND EXISTING CUSTOMERS.

 

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